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Excessive or poorly regulated glutamate signaling, NMDA receptor overactivity, undermethylation, high histamine, low zinc or magnesium, oxidative stress, toxic burden, mitochondrial strain, and repeated exposure to processed-food glutamates may all contribute to a brain that stays “too on.” The result can be intrusive thoughts, mental looping, sensory overload, insomnia, inner urgency, and difficulty disengaging from fears even when they are recognized as irrational