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Graphical abstract Keywords: antioxidants, bilirubin, cell signalling, immunomodulation Highlights • Bilirubin is a potentially toxic molecule, but it also has physiological functions • In some pathological conditions, a low bilirubin concentration may be a potential risk factor • A slightly elevated serum bilirubin concentration may have health benefits • It would be advisable to establish new reference intervals/limit concentrations for bilirubin • Different limits could be investigated and/or established in relation to specific clinical conditions Abstract For decades, bilirubin was thought to be merely a degradation product of the hem, a potentially toxic compound and a molecule with no specific physiological function

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doi: 10.1016/j.yfrne.2017.10.003 94 RecouvreuxMVGuidaMCRifkinDBBecu-VillalobosDDíaz-TorgaG