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Mast cells release histamine and other mediators that recruit immune and endothelial cells to the wound site, thus initiating tissue remodeling and vascular response.² Thymosin Beta-4 Fragment (17–23) is also linked to angiogenesis, likely through indirect stimulation of vascular endothelial cells

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those continuing on semaglutide 2.4 mg achieved a 7.9% BW reduction at study end, while patients on placebo exhibited a BW gain of 6.9% 25