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A change in the chemical environment resultant from (non)covalent interactions causes a detectable change in the resonance frequency (typically reported as a ‘chemical shift’) and the coupling of nuclei with a nonzero nuclear spin (e.g., 1 H, 13 C, 15 N) in the magnetic field of the NMR spectrometer
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Specifically, ebselen, an organo-Se compound that mimics GPX, has been shown to suppress superoxide anion formation and release of NO as well as to scavenge peroxynitrite and protect against lipid peroxidation, which is consistent with its proposed ability to prevent OS