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doi: 10.1016/j.cell.2022.07.020 [DOI] [PMC free article] [PubMed] [Google Scholar] 58

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According to our findings in the present and previous [17] studies, it takes a certain time for p38 and Nrf2 to be activated by quercetin and for gene transcription and protein expression of Nrf2 target proteins (MRP-1, GCLC and GCLM) to be induced, with maximal protein expression observed after 18 h of incubation