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They are multidomain proteins with three PSD95-DIgA-ZO-1 (PDZ) domains, a central Src homology 3 (SH3) domain, and a region with homology to guanylate kinase (GUK) (Van Itallie and Anderson, 2014) and actin-binding regions, which enable them to organize TJ components and link them to the cytoskeleton
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