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in fact, exposure to CM from breast cancer (SKBR3), astrocytes, and brain endothelial cells induces the release of multiple tumor-supportive mediators including CCL5, CXCL8/IL-8, pentraxin 3 (PTX3), colony stimulating factor 2 (CSF2), retinol binding protein 4 (RBP4), fms related receptor tyrosine kinase 3 ligand (FLT3LG), platelet-derived growth factor subunit A (PDGFA), and BDNF, which drive tropomyosin receptor kinase B (TrkB) and human epidermal growth factor receptor 2 (HER2) activation and stimulate proliferation of breast cancer cells and endothelial targets, highlighting the ability of HMC3-secreted factors to promote tumor growth and neurovascular niche formation (320)
