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Overall, although the biochemical (catalytic and ligandin) properties of representative members from almost all GST classes have been studied, sometimes extensively, the physiological role of most of them remains to be identified, essentially because the existence of several close isoforms in given classes may have hampered their characterization by reverse-genetic approaches

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Results of Imatinib Mesylate (STI571) in Philadelphia Chromosome Positive Chronic Myelogenous Leukemia in Chronic Phase (Ph+CML-CP) Post Interferon Alpha (IFN) Failure