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Superoxide radical (O 2 − ) is the initial reactive species produced during these reactions, serving as the precursor for additional reactive radicals, including H 2 O 2 and the hydroxyl radical (OH − ), one of the most potent free radical species that can react with a wide range of cellular constituents [36]

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Combining a PI3K inhibitor with a PARP inhibitor provides an effective therapy for BRCA1-related breast cancer