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In an OIS model induced by Nras G12v overexpression in hepatocytes of immunodeficient Nod Scid Gamma (NSG) mice, senescent cells were successfully eliminated when treated with the anti-uPAR CAR-T cells

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5.1.2 Histone modification disruptions 5.1.2.1 Repressive and activating chromatin marks EED exposure systematically alters the chromatin landscape through modifications to key histone marks