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Bidirectional regulatory contradiction: METTL3 simultaneously mediates the m 6 A modification of the 5′UTR of dCK mRNA, promotes nuclear export and translation through YTHDC1, and enhances gemcitabine activation, while FTO demethylates dCK, reducing its stability, forming a balanced antagonism that promotes drug resistance/sensitization
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Discussion This analysis provides a snapshot of the landscape of depression clinical trials registered on ClinicalTrials.gov, which results provide the basis for the treatment and prevention of diseases within depression, as well as the characteristics of trial design, location, and intervention type
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