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Frontiers | Excessive alcohol consumption: a driver of metabolic dysfunction and inflammation

[DOI] [PubMed] [Google Scholar] 61.Small D.M., Coombes J.S., Bennett N., Johnson D.W., Gobe G.C

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An elevated IRS/CIRS ratio reflects the net impact of IRS activation alongside the disruption of immune tolerance, whereas a diminished IRS/CIRS ratio suggests that immunosuppressive CIRS effects may be more pronounced