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In a pilot RNA-Seq study using ribodepleted RNA from engorged nymphs infected with WT strain B31, only approximately 6,700 reads mapped to protein coding genes (0.034% of approximately 20 million total raw reads) (Supplemental Table 1
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Despite its promise as a combinatory approach with conventional cancer treatments, ferroptosis induction carries risks of adverse effects such as myelosuppression, hepatorenal toxicity, and secondary tumor development (59)
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