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Strengths and weaknesses of the study Comparisons between herniated, degenerated, and non-degenerated (scoliotic) discs benefited from the use of human tissues that were believed to be painful, and they were examined using techniques (including immunofluorescence and confocal microscopy) that yielded high-resolution images of degenerative features, including exposed integrin binding sites (Fig

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However, the planned increment to 12000 mg/day was not carried out as the bulk volume of curcumin was not well tolerated in the patients beyond 8000 mg/day dose