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1) were assessed by pathway enrichment in MetaboAnalyst 6.0 using the Small Molecule Pathway Database (SMPDB) with 99 metabolite sets from normal human metabolic pathways and was enriched for Methionine Metabolism, Phenylacetate Metabolism, Pantothenate and CoA Biosynthesis, Pyrimidine Metabolism, Glycine and Serine Metabolism, Arginine and Proline Metabolism, Riboflavin Metabolism and Betaine Metabolism (Fig

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We assessed the methodological quality of the included articles according to the Cochrane risk of bias criteria [11]