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In addition, preliminary data suggests that ERS1 knockout in a human preadipocyte cell strain (SGBS) resulted in impairment of adipogenesis as well as basal and insulin-stimulated glucose uptake, while ESR2 knockout resulted in an increase in glucose uptake and an increasing adipogenesis trend

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In some cases, the physiological underpinnings overlap, which indicates that some of the therapies used to treat IBD can be just as effective for IBS