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Comparison of the prevalence of deficient ribo­flavin status among these studies is often difficult because the method of EGR AC assessment has not been standardized and as shown in a systematic evaluation of the existing methods, variations in the laboratory protocols applied in various studies could produce significantly different results (Hill et al., 2009)

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Once hemolysis is ruled out, then assessment of primary parenchymal disease versus disease of the biliary tree is completed by evaluating the clinical presentation, laboratory values, and imaging of the biliary tree and abdomen for possible evidence of biliary or pancreatic disease