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A reduction in HDAC9 expression at both the mRNA and protein levels was also observed in the hippocampus and PFC of 5xFAD mice, a widely used model of AD [71]

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The main pathological hallmarks of PD include loss of dopaminergic neurons in the substantia nigra and the presence of intraneural Lewy bodies, with motor and non-motor symptoms (Bloem et al., 2021)