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However, hepatic synthetic functions and cholesterol excretion into bile are enhanced during pregnancy ( 5.3 Progesterone There is an upregulation of serum progesterone levels during normal pregnancy, which suppresses hepatic clearance function, and increases hepatic synthetic functions ( 5.4 Growth hormone/insulin-like growth factor 1 The pituitary gland produces GH, which modulates the production of IGF-1 via the GH receptor (GHR)

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Comparison with AOD-9604 – AOD-9604 is a modified version of Fragment 176-191 with an additional N-terminal tyrosine residue