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the most common were dry mouth and insomnia.” — Astrup et al., The Lancet → Who Should Avoid Tesofensine → Individuals with uncontrolled hypertension or cardiovascular disease → Anyone on SSRIs, SNRIs, or MAO inhibitors (risk of serotonin syndrome) → Those with a history of severe anxiety, panic disorder, or arrhythmias → Pregnant or breastfeeding women (due to lack of safety data) → Best Practices for Safety → Start at 0.25 mg/day and gradually titrate → Avoid stacking with caffeine , yohimbine , or stim-heavy pre-workouts → Monitor blood pressure, heart rate, and sleep quality → Discontinue use if side effects worsen or persist beyond the adaptation period (7–10 days) Although Tesofensine has a relatively clean side effect profile at moderate doses, it’s still a powerful central agent

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Both options can be effective, but they differ significantly in total investment, durability of results, and medical candidacy