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In a two-week double-blind, placebo-controlled trial, individuals taking ME-3 achieved reductions in oxidized LDL-cholesterol (71 U/l to 63 U/l), BDC-LDL (23.8 umol/l to 22.0 umol/l), and triglycerides (2.1 mmol/l to 1.9 mmol/l) and beneficial increases in PON (110.0 U/l to 133.4 U/l) and HDL-cholesterol (1.4 mmol/l to 1.5 mmol/l)

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Mechanism and gene expression Pickart and colleagues used Broad Institute Connectivity Map data to show GHK-Cu modulates expression of more than 4,000 human genes, with shifts toward patterns associated with younger tissue