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It was run using a panel of 390 normal samples, which we built by selecting random normal samples across different datasets: ICGC DCC ESAD-UK 107 , TCGA 108 , the MSKCC–WCM–NYGC HRD project 109 , The Cancer Alliance at NYGC 110 , the Hartwig Medical Foundation ( ICGC PanCancer Analysis of Whole Genomes 7 , CCLE 2 and other publications 111,112,113,114,115,116

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10.1038/s41586-019-1707-0 Nature 18 DolmaS.LessnickS