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Research involving FOXO4-DRI has discussed: FOXO4–p53 protein interaction disruption p53 TAD2 competitive binding studies Senescent-cell selective apoptosis BAX/BCL-2/caspase-3 signalling pathways SASP suppression and inflammatory signalling Vascular-ageing and endothelial-senescence research Chondrocyte and cartilage-regeneration studies Comparative senolytic pathway investigations Published scientific investigations have demonstrated that FOXO4-DRI selectively induces apoptosis in senescent cells by disrupting FOXO4-mediated nuclear retention of p53
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Amount:100mg
10.1093/toxsci/kfj111 63 KlicekR.KolencD.SuranJ.DrmicD.BrcicL.AralicaG.et al (2013)
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