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This integrated evidence strategy is intended to confirm clinical practice and inform payer evaluation frameworks

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1 Five polyphenols that had been previously shown to induce apoptosis in leukaemia cells (quercetin, apigenin, emodin, rhein and cis- stilbene) 2 were combined with doxorubicin or etoposide in two lymphoid (CCRF-CEM and Jurkat) and two myeloid (THP-1 and KG1a) cell lines