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De Souza, C

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In accordance with this notion, it is important to mention that endothelial cells can undergo extensive modifications, in particular in the context of hypoxia by disrupting redox balance (producing ROS), or during endoplasmic reticulum stress, in mitochondrial dysfunction, upregulations of enzymes or adhesion molecules, and discharge of proinflammatory factors (producing chemokines) [29,30]