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Aldehyde-containing neo-epitopes as shared or structurally related determinants, favoring the intermolecular spreading of autoimmunity between proteins and from proteins to DNA The ability of HNE to form adducts with multiple macromolecules, i.e., a broad array of conjugates sharing the HNE moiety as a common epitope, might partly explain the wide range of autoantibody responses occurring in SLE and SS
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