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Yes, among type 2 diabetics, but it;’s yet to be determined if that’s the case for healthy people taking the drug Metformin Blunts the Beneficial Effects of Exercise It’s been shown that 150 minutes of moderate-intensity exercise per week prevented the progression of pre-diabetes to type 2 diabetes by 60% Comparatively, metformin prevented this progression by 30% in pre-diabetics You might think metformin and exercise have a synergistic effect, but multiple randomized control trials have shown the opposite seems to be true “Taking metformin in the context of either aerobic exercise or strength training seems to blunt many of the positive effects of exercise.” – Dr