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After 30 days on the 3 mg dose, increase the dose to 7 mg once daily

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GHR binding induces receptor dimerisation and activation of the associated Janus kinase 2 (JAK2), triggering a phosphorylation cascade that activates Signal Transducer and Activator of Transcription 5 (STAT5) — the primary transcriptional mediator of GH’s genomic effects, including IGF-1 gene expression