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This nuclear localization in elderly Leydig cells correlated with reduced expression of 3β-HSD, a crucial enzyme for testosterone synthesis, suggesting a link between nuclear FOXO4 and age-related decline in testosterone production [2]
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However, investigators have shown that β-carotene concentrations in serum were associated with better neurological volumes and parameters, most likely due to antioxidant activity maintaining the glymphatic system function of the brain [106]
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