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MS2734 inhibited the methyltransferase activity of NNMT with IC 50 14 ± 1.5 μM

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The possible involvement of sensory neurons in the salutary effects of NaBPC157 (10 µg/kg, 10 ng/kg i.p.) was studied with capsaicin which has quite distinct effects on sensory neurons: high dose administration to adult animals (125 mg/kg s.c., (subcutaneously) three months of age) or administration (50 mg/kg s.c.) to neonatal animals (seven days of age) destroys sensory fibers, whereas a low dose (500 µg/kg i.p.) activates a neurotransmitter release and protective effects on the mucosa