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Epigenetic modifications also impair the function of antioxidant defense genes, including SOD and nuclear factor erythroid 2-related factor 2 (Nrf2), thereby worsening β-cell dysfunction and oxidative damage [29-31]
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further examined the gene expression of tight junction proteins and revealed significantly decreased occludin and β-catenin gene expression in the rabbits that underwent raised-intensity phonation compared with control
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