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Hepatic gluconeogenic enzyme activities are favorably linked with blood glucose level, while hepatic glucokinase activity is negatively associated (Tirone and Brunicardi, 2001)
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These data can perhaps be mined to discover potential improvements on the traditional C–P bond-containing phosphonamidite bioisostere described above or to introduce the phosphonamidate moiety as an amide bioisostere itself, albeit with intracellular metabolic lability
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