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It has been shown that low serum vitamin B 12 is associated with a 2- to 4-fold higher risk of cognitive impairment.50 The prevalence of low serum vitamin B 12 has been reported to be significantly higher in the people with Alzheimer’s disease (AD).52 However, the causal relationship between vitamin B 12 deficiency and the development of AD remains controversial

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Because of its potential to enhance metabolic efficiency and endurance, MOTS-c is on the WADA Prohibited List in category S4