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(8) Furthermore, FOXO4’s role in the IIS pathway suggests it might modulate the actions of diet and environmental factors on cell aging, acting as a mediator between external factors and cellular longevity pathways
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as some hyperuricemic patients may never develop the disease, and blood urate levels may be normal during an acute attack (in one study, 14% of patients had blood uric acid levels of 4.85 mg/dL saw a 0.78 mg/dL reduction)
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