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Common Symptoms of B12 Deficiency When Vitamin B12 levels drop too low you can experience a variety of symptoms including: Impaired mental functionality – poor memory, brain fog, confusion, anxiety, irritability Muscular weaknesses – overall muscle weakness, tender calves, numbness and/or tingling in your extremities, Sensations of pins and needles due to nerve damage, Glossitis and mouth ulcers, Mood changes: depression, psychosis and irritability, Some loss in sense of touch, walking and vision problems, Appetite Changes – Loss of appetite and weight loss, anemia, Low energy – general fatigue (especially in the afternoon), shortness of breath, pale or yellowing complexion, Migraine-like Symptoms – lightheadedness, dizziness, blurry vision, sensitivity to light, etc… What Causes a Vitamin B12 Deficiency