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Under near-infrared-II (NIR-II) irradiation, this system simultaneously induces ferroptosis via PTT-enhanced Fenton-like reactions and cuproptosis through DLAT aggregation, demonstrating potent antimetastatic efficacy when combined with immune checkpoint blockade

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Moreover, when GPX3-/- knock-out mice were exposed to surgery-induced chronic kidney disease (CKD), these mice displayed decreased left ventricular fractional shortening, increased platelet aggregation, and microthrombi in the myocardium [41]