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When the degree and duration of intestinal hypoperfusion are severe and long, intestinal reperfusion may aggravate organ damage by excessive activation of polymorphonuclear neutrophils, oxidative stress, and pro-inflammatory mediators and trigger inflammatory responses

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TRG sensitized chemo-resistant head and neck cancer (HNC) cells to in vitro and in vivo RSL3 treatment by decreasing the activity of the Nrf2-ARE pathway (Shin et al., 2018)

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