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Neuropeptide Signaling Modulators The arcuate nucleus of the hypothalamus, the primary neural signaling site for peripheral appetite-regulating hormones, is mainly composed of two types of appetite-regulating neurons: 1), those expressing the anorexigenic (appetite-suppressing) neuropeptides pro-opiomelanocortin (POMC) and cocaine- and amphetamine-regulated transcript (CART) and 2) those expressing the orexigenic (appetite-stimulating) neuropeptides agouti-related peptide (AgRP) and neuropeptide Y (NPY)