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Similar to the GPX4 crystal structures that we solved with the other five GPX4 binders (RSL3, ML162, CDS9, TMT10, and MAC-5576), residues L166-F170 undergo a conformational change from a loop into a helix, suggesting a shared GPX4 conformational change upon small molecule binding to C66 site
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BMC Psychiatry 14, 321
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