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The JNK-interacting protein-1 scaffold protein targets MAPK phosphatase-7 to dephosphorylate JNK

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Senescent cells are cells that have permanently halted their cell cycle ('replicative arrest') but resist apoptosis—sometimes called 'zombie cells.' They accumulate with age in multiple tissues and secrete a pro-inflammatory cocktail called the Senescence-Associated Secretory Phenotype (SASP), containing IL-6, IL-8, MMP-3, MMP-9, TNF-α, and other factors that damage surrounding healthy tissue