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In addition, due to the broad action spectrum, understanding more dynamic and integrated NRF2-mediated metabolism and immunity of different cell types in a disease context will facilitate discovery of molecular pathology and new treatment strategies

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87,192 This relocation is mediated via the mTORC1 pathway and the lack of three aromatic amino acids, tyrosine, tryptophan, and phenylalanine (YWF), which transmit their signals upstream of mTORC1 by disrupting SESTRIN3 binding to the GATOR2 complex (Fig