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3 Another study showed that vitamin B12 levels were significantly lower after 4 months of treatment with isotretinoin for acne vulgaris

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It blocks the synthesis of DNA, mRNA, and protein synthesis by interacting with purine bases on gDNA or mitochondrial DNA, inhibiting DNA replication and promoting cell apoptosis ( A previous study has found that QUE enhanced the growth inhibition of CIS in HepG2 HCC cells by up-regulating p16 expression ( As an effective chemotherapeutic agent, CIS is used to treat various human cancers