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In AhR-expressing intratumoural CD8 + T cells, active kynurenine transport activates AhR-dependent transcription of PDCD1 , whereas IL-2–STAT5-driven TPH1 expression promotes tryptophan catabolism to 5-hydroxytryptophan (5-HTP), further enabling AhR-mediated induction of exhaustion-associated genes such as PDCD1 , LAG3 , ENTPD1 (CD39) and HAVCR2 128,129

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The strategy of covalently conjugating metal-based anticancer agents to amphiphilic polymers, that could self-assemble into nanoparticles, could present a method for the tumor-selective anticancer therapy