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Traumatic Brain Injury Research Traumatic brain injury (TBI) produces primary mechanical damage (axonal shearing, contusion) and secondary injury cascades including excitotoxicity (glutamate-driven NMDA overactivation), neuroinflammation (microglial activation, pro-inflammatory cytokine production), oxidative stress, and disruption of the blood-brain barrier (BBB)

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Parkinson disease from mendelian forms to genetic susceptibility: new molecular insights into the neurodegeneration process