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An even higher discrepancy exists between the alignments of just the NBD1 + R-domain region (610–927) performed to account for domain motions between structures (IFwide to AlphaFold2 model: 2.6 Å versus 7MPE to AlphaFold2 model: 10.7 Å)

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As of now, there is no universal “cure” for Vitamin B12 deficiency, as the optimal approach hinges on the specific cause and severity of the condition