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Mechanically, LPS interacts with host Toll-like receptors (TLRs), especially TLR4, triggering intracellular signaling cascades that lead to AA metabolic remodeling
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Furthermore, oral administration of the extract (30–300 mg/kg) demonstrated a dose-dependent antihypertensive effect in rats, which was notably diminished when L-NAME or methylene blue was injected (Lapa et al., 2011)
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