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Although, the M1/M2 classification is generally oversimplified, under specific immunopathologic conditions, such as the tumor-immune system interplay or the host–pathogen interaction during microbial pathogenesis, M1 and M2 macrophages were shown to harness contrasting signalizations and under these circumstances, the opposing activities indeed follow the macrophage M1/M2 phenotypes paradigm
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P., “Nanotechnological Strategies for Nerve Growth Factor Delivery: Therapeutic Implications in Alzheimer's Disease,” Pharmacological Research 120 (2017): 68–87
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