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Of patients in the study group who had a prior hypersensitivity reaction after sulfonamide antimicrobial receipt, 96 out of 969 (9.9%) had an allergic reaction within 30 days after receipt of a sulfonamide nonantimicrobial compared to 315 out of 19,257 (1.6%) patients in the comparison group who experienced an allergic reaction within 30 days after receipt of a sulfonamide nonantimicrobial without prior hypersensitivity after sulfonamide antimicrobial receipt

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Description – Tretinoin works by promoting peeling of the skin and replacing older skin with newer skin