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Analysis of the synovial tissue and popliteal lymph nodes (pLN) by flow cytometry analysis at this early time points (25 days after immunization) did not reveal any changes in the total synovial CD4 + T-cell or B220 + B-cell frequencies (Supplementary Fig

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However, because those types of SNPs are not currently reported in commercial tests, individuals may require either a trial-and-error approach by supplementing with one particular form of B 12 at a time, or they might simply use a supplement with a combination of all 3 naturally occurring forms of B 12 that are commercially available for a better chance of achieving faster clinical results