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Gene-Expression & Regenerative Research Research involving GHK-Cu has investigated its interaction with gene-expression pathways associated with: Cellular-repair and maintenance pathways Tissue-remodeling and regenerative signaling Antioxidant-defense mechanisms Stem-cell–related signaling pathways Extracellular-matrix maintenance Inflammation-related signaling pathways Studies commonly investigate how GHK-Cu may influence broader regenerative and physiological-resilience pathways associated with healthy-aging and tissue-maintenance research

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STAR★METHODS Detailed methods are provided and include the following: KEY RESOURCES TABLE CONTACT FOR REAGENT AND RESOURCE SHARING Further information and requests for resources and reagents should be directed to and will be fulfilled by the Lead Contact, Elaine Hsiao ([email protected]) EXPERIMENTAL MODELS AND SUBJECT DETAILS Mice 3–4 week old SPF wildtype Swiss Webster mice (Taconic Farms), GF wildtype Swiss Webster mice (Taconic Farms) and SPF C3HeB/FeJ KCNA1 KO mice (Jackson Laboratories) were bred in UCLA’s Center for Health Sciences Barrier Facility